Identification of genes responsive to ultrasound in human leukemia U937 cells

Here, the effects of non-thermal low intensity pulsed ultrasound (LIPUS) on the gene expression in human lymphoma U937 cells were investigated using by an Affymetrix GeneChip system. Six hours after LIPUS treatment (0.3 W/cm2 for 1 min), apoptosis (143.8%, meanSD) with minimal cell lysis was observed. At 3 h post-treatment, LIPUS down-regulated 193 genes and up-regulated 201 genes by >1.5-fold.

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Tabuchi Y, Takasaki I, Zhao QL, Wada S, Hori T, Feril LB Jr, Tachibana K, Nomura T, Kondo T