Cellular and Molecular Changes in Psoriasis Lesions Inducedby Ustekinumab: Distinct Differences in Responders vs. Non responders

GSE117239

Homo sapiens

322 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Ustekinumab provides clinical benefit to psoriasis patients, but precise cellular and molecular changes underlying its therapeutic utility are not yet fully understood. To assess differences between ustekinumab responders vs. non responders in modulating specific inflammatory pathways and provide reference data for exploring molecular effects of next-generation interleukin(IL)-17 and IL-23-antagonists in psoriasis.

PubMed ID

30703387

Publication Title

Modulation of inflammatory gene transcripts in psoriasis vulgaris: Differences between ustekinumab and etanercept.

Total Samples

324

Submitter’s Institution

The Rockefeller University

Authors

Brodmerkel C, Li K, Garcet S, Hayden K, Chiricozzi A, Novitskaya I, Fuentes-Duculan J, Suarez-Farinas M, Campbell K, Krueger JG

Source Repository

Gene Expression Omnibus (GEO)

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