Activity Deprivation-Induced Transcriptional Changes in the P21 Cochlear Nucleus

GSE11726

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve. Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes. Thus, an additional factor not dependent on action potential-mediated signaling must also regulate transcriptional responses to deafferentation in the CN.

PubMed ID

18945907

Publication Title

Afferent deprivation elicits a transcriptional response associated with neuronal survival after a critical period in the mouse cochlear nucleus.

Total Samples

Submitter’s Institution

University of Washington

Authors

Harris JA, Iguchi F, Seidl AH, Lurie DI, Rubel EW

Source Repository

Gene Expression Omnibus (GEO)

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