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Accession IconGSE11809

Lung transcriptome from M. avium infected WT, IFNg-/- and IRF1-/- mice

Organism Icon Mus musculus
Sample Icon 23 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

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Description
Mycobacterium avium infection in mice induces granuloma necrosis in the lung which is dependent on IFNg. IRF1 is a transcription factor activated by IFNg signaling. The effect of IFNg and IRF1 on immunopathology and transcriptional changes in the lung were analysed using gene-deficient mice.
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