Expression data from LNCaP cells transfected with SOX4 cDNA, SOX4 siRNA or GFP cDNA

SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have either eliminated SOX4 using siRNA or overexpressed a SOX4 cDNA and compared the gene expression patterns against control GFP transfections to identify SOX4 target genes.

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Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS