Topoisomerase II inhibition involves characteristic chromosomal expression patterns: Doxorubicin study

A variety of important anticancer drugs kill cells by increasing cellular levels of topoisomerase II-DNA cleavage complex. The anthracycline anticancer drug doxorubicin forms a stable ternary complex with DNA and topoisomerase IIa, thereby inhibiting the normal function of the enzyme.

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Reymann S, Borlak J