Skeletal muscles of untreated children with juvenile dermatomyositis

Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months.

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Chen YW, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM