Anti-Nogo-A antibody treatment of Rat Hippocampal Slice Cultures

The neurite outgrowth inhibitory myelin protein Nogo-A has been well studied in the context of central nervous system (CNS) injury and disease. We studied the effects of the application of neutralizing anti-Nogo-A antibodies (11C7 and 7B12) in intact CNS tissue in vitro using rat organotypic hippocampal slice cultures. This study had the purpose of elucidating the role of Nogo-A in the adult intact CNS and determining the consequences of its neutralization through antibody application.

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Craveiro LM, Hakkoum D, Weinmann O, Montani L, Stoppini L, Schwab ME