IL-8 released from human pancreatic cancer and tumor associated stromal cells signals through a CXCR2-ERK1/2 axis to induce muscle atrophy

Serum levels of interleukin-8 (IL-8) are increased in the serum of people with pancreatic cancer and associated with the loss of body weight and low muscle mass. We have identified that systemic (intraperitoneal) injection of IL-8 into mice induces significant skeletal muscle atrophy. Transcriptional profiling of muscle harvested from these same mice identified the genes and biological processes associated with this IL-8 induced atrophy including gene clusters related to chromatin modification, muscle cell differentiation, and ubiquitin ligase complex.

12

Callaway CS, Delitto AE, Patel R, Nosacka RL, D'Lugos AC, Delitto D, Deyhle MR, Trevino JG, Judge SM, Judge AR