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Accession IconGSE139334

Gene expression analysis of fibroblasts of systemic sclerosis patients silenced for lncRNA H19X

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description
LncRNA H19X was silienced in dermal fibroblats of systemic sclerosis patients with antisense oligonuclotides. The hypothesis tested in the present study was that H19X is an important factor in the development of TGFb-driven fibrosis. Results provide important information about the role H19X in fibroblasts in particolar on extracellular matrix production and cell cycle regulation.
PubMed ID
Total Samples
12
Submitter’s Institution

Samples

Show of 12 Total Samples
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Specimen part
Disease
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Processing Information
Additional Metadata
SSc2_scrambled + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
scrambled control
SSc2_H19X ASO + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
antisense oligonucleotide targeting h19x
SSc3_scrambled + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
scrambled control
SSc3_H19X ASO + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
antisense oligonucleotide targeting h19x
SSc4_scrambled + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
scrambled control
SSc5_H19X ASO + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
antisense oligonucleotide targeting h19x
SSc5_scrambled + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
scrambled control
SSc6_H19X ASO + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
antisense oligonucleotide targeting h19x
SSc1_scrambled + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
scrambled control
SSc1_H19X ASO + TGFβ
dermal fibroblasts
systemic sclerosis
systemic sclerosis
antisense oligonucleotide targeting h19x
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