Gene expression data of cSHMT mutant, heterozygous, and wild-type mouse colons

Folate-mediated one-carbon metabolism is required for purine, thymidylate, and S-adenosylmethionine synthesis. Impairments in folate metabolism diminish cellular methylation potential and genome stability. Cytoplasmic serine hydroxymethyl transferase (cSHMT) regulates partitioning between thymidylate and SAM biosynthesis. These experiments were designed to determine if mutations in cSHMT led to alterations in gene expression.

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Macfarlane AJ, Perry CA, McEntee MF, Lin DM, Stover PJ