Riboflavin depletion impairs cell proliferation in intestinal cells: Identification of mechanisms and consequences

Microarray analysis has been applied to the cell proliferation in a human colonic cel line, Caco-2. We have shown previously that a moderate riboflavin depletion around weaning has a profound impact on the structure and function of the small intestine of the rat, which is not reversible following riboflavin repletion. In this study we have modelled riboflavin deficiency in a human cell line, shown irreversible loss of cell viability associated with impaired mitosis and identified candidate effectors of riboflavin depletion in the cell.

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Nakano E, Mushtaq S, Heath PR, Lee ES, Bury JP, Riley SA, Powers HJ, Corfe BM