EGR1 regulates metastatic potential of v-src transformed chicken sarcoma cell lines

A model of tumor metastasis based on v-src transformed immortalized cell lines was developed. The model consists of highly metastatic PR9692 cell line and a derived clone PR9692-E9 which has lost the metastatic abilities. Introduction of exogenous EGR1 gene into the non-metastasizing PR9692-E9 cells completely restores the metastatic potential. Revealed changes in gene expression provide insight into the molecular mechanisms contolling metastatic behavior of sarcoma cells.

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Cermák V, Kosla J, Plachý J, Trejbalová K, Hejnar J, Dvorák M