p73 activity and rapamycin treatment: ChIP-on-Chip and gene expression profiling studies

GSE15719

Homo sapiens

8 Downloadable Samples

Affymetrix Human Tiling 2.0R Set, Array 1 (hs35bp01r), Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

p73 is a p53 family transcription factor that plays critical roles during development and tumor suppression. We analyzed p73 activity using a combination of ChIP-on-Chip and gene expression profiling, both at baseline and after treatment with the mTOR inhibitor rapamycin.

PubMed ID

21245298

Publication Title

Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis.

Total Samples

Submitter’s Institution

Vanderbilt University Medical Center

Authors

Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA

Source Repository

Gene Expression Omnibus (GEO)

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