Heart Failure Associated Changes in Alternative Splicing of Sarcomere Genes

GSE16499

Homo sapiens

28 Downloadable Samples

Affymetrix Human Human Exon 1.0 ST Array (huex10st), Affymetrix Human Exon 1.0 ST Array [transcript (gene) version (huex10st)

Submitter Supplied Information

Description

Alternative mRNA splicing is an important mechanism for regulation of gene expression. Changes in gene expression contribute to the pathogenesis of heart failure. However, changes in mRNA splicing have not been systematically examined in heart disease. We hypothesized that mRNA splicing is changed in diseased hearts.

PubMed ID

20124440

Publication Title

Heart failure-associated changes in RNA splicing of sarcomere genes.

Total Samples

Submitter’s Institution

Boston Children's Hospital

Authors

Kong SW, Hu YW, Ho JW, Ikeda S, Polster S, John R, Hall JL, Bisping E, Pieske B, dos Remedios CG, Pu WT

Source Repository

Gene Expression Omnibus (GEO)

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