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Accession IconGSE17584

Transcriptional effects of CRP* expression in Escherichia coli

Organism Icon Escherichia coli
Sample Icon 14 Downloadable Samples
Technology Badge Icon Affymetrix E. coli Genome 2.0 Array (ecoli2)

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Description
Escherichia coli exhibits diauxic growth in sugar mixtures due to CRP-mediated catabolite repression and inducer exclusion related to phosphotransferase system enzyme activity. Replacement of the native crp gene with a catabolite repression mutant (referred to as crp*) alleviates diauxic effects in E. coli and enables co-utilization of glucose and other sugars. While previous studies have examined the effects of expressing CRP* mutants on the expression of specific catabolic genes, little is known about the global transcriptional effects of CRP* expression.
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