In vitro differentiation of P19CL6 cardiogenic embryonic carcinoma cells

Pluripotent P19CL6 embryonic carcinoma cells can be differentiated to a cardiac lineage by culture in the presence of DMSO. The goal of this study was to characterize temporal gene expression patterns associated with cardiogenic differentiation. Gene expression analysis was conducted on differentiating P19CL6 cells at several time points following induction with 1% DMSO. Samples were processed for analysis by Affymetrix GeneChip.

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Barth JL, Clark CD, Fresco VM, Knoll EP, Lee B, Argraves WS, Lee KH