Gene expression comparison of drug-resistant Panc1/mock cells and Panc1 cells expressing wildtype syk

We recently identified the nonreceptor tyrosine kinase syk as a tumor suppressor in pancreatic ductal adenocarcinoma cells. Reintroduction of syk into Panc1 cells promoted a more differentiated phenotype and retarded invasion and tumorigenic growth. Gene array analysis identified over 2,000 transcripts differentially expressed at FDR<0.01. Among these were members of the MMP2 axis, which were subsequently shown to regulate Panc1 invasion.

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Layton T, Stalens C, Gunderson F, Goodison S, Silletti S