Kidney Stone Induces Developmental Stage-specific Alterations in Gene Expression

OBJECTIVES: Kidney stone diseases are common in premature infants, but the underlying molecular and cellular mechanisms are not fully defined. We carried out a prospective observational study using microarray analysis to identify factors that may be crucial for the initiation and progression of stone-induced injury in the developing mouse kidney.

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Chen J, Chen Y, Capizzi S, Yang M, Deng L, Bledsoe SB, Evan AP, Tischfield JA, Sahota A