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Accession IconGSE19946

In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation

Organism Icon Mus musculus
Sample Icon 9 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

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Description
To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1.
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