Dose-dependent gene expression analysis of cardiomyocytes treated with DEHP (1-50 ug/mL)

We used microarrays to expression profile cardiomyocytes from neonatal Sprague-Dawley rats treated with 1 to 50 ug/mL DEHP and control (0.1% DMSO) to identify changes in gene expression related to connexin-43 expression, calcium handling, arrhythmogenesis and mechanical motion.

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Posnack NG, Lee NH, Brown R, Sarvazyan N