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Accession IconGSE22581

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

Organism Icon Mustela putorius furo
Sample Icon 20 Downloadable Samples
Technology Badge Icon Affymetrix Canine Genome 2.0 Array (canine2)

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Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets.
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