Comparison of Expression profile between CD3-CD56dimCD16+ CD57+ and CD57neg NK cells

GSE23695

Homo sapiens

6 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

Thirty to 60% of CD56dimCD16bright NK cells in healthy adults express CD57, which is not expressed on immature CD56bright NK cells or fetal and newborn NK cells. We hypothesized that CD57+ NK cells within the CD56dim mature NK cell subset are highly mature and might be terminally differentiated.

PubMed ID

20733159

Publication Title

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset.

Total Samples

Submitter’s Institution

University of California San Francisco

Authors

Lopez-Vergès S, Milush JM, Pandey S, York VA, Arakawa-Hoyt J, Pircher H, Norris PJ, Nixon DF, Lanier LL

Source Repository

Gene Expression Omnibus (GEO)

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