Evaluation of gene expression data generated from expired Affymetrix GeneChip microarrays using MAQC reference RNA samples

The Affymetrix GeneChip system is a commonly used platform for microarray analysis but the technology is inherently expensive. Unfortunately, changes in experimental planning and execution, such as the unavailability of previously anticipated samples or a shift in research focus, may render significant numbers of pre-purchased GeneChip microarrays unprocessed before their manufacturers expiration dates. Researchers and microarray core facilities wonder whether expired microarrays are still useful for gene expression analysis.

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Wen Z, Wang C, Shi Q, Huang Y, Su Z, Hong H, Tong W, Shi L