Expression data from human amnion mesenchymal cells treated with interleukin-1-beta for 1hr and 8hr

Premature birth continues to be a challenging pregnancy complication, and a body of literature indicates that inflammation can contribute to premature delivery by converting a receptive uterine environment to a hostile one. Cytokines have been demonstrated to provoke up-regulation of inflammatory genes (e.g. interleukin-1, 6, and 8, tumor necrosis factor-alpha, cyclooxygenase-2, and microsomal prostaglandin E synthase-1).

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Li R, Ackerman WE 4th, Summerfield TL, Yu L, Gulati P, Zhang J, Huang K, Romero R, Kniss DA