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Accession IconGSE26369

LIF-Dependent, Pluripotent Stem Cells Established from Inner Cell Mass of Porcine Embryos

Organism Icon Sus scrofa
Sample Icon 3 Downloadable Samples
Technology Badge Icon Affymetrix Porcine Genome Array (porcine)

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The pig is important for agriculture and as an animal model in human and veterinary medicine, yet, despite over 20 years of effort, it has proved a difficult species from which to generate pluripotent stem cells analogous to those derived from mouse embryos. Here we report the production of LIF-dependent, so called nave type, pluripotent stem cells from the inner cell mass of porcine blastocysts by up-regulating expression of KLF4 and POU5F1. These cells resemble mouse ES cells and are distinct from the FGF2-dependent, induced pluripotent cell type derived from porcine somatic cells.
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