Expression data from BCL11A-null and wild-type bone marrow erythroid pregenitors

GSE28333

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals.

PubMed ID

21998251

Publication Title

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Total Samples

Submitter’s Institution

UT Southwestern Medical Center

Authors

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH

Source Repository

Gene Expression Omnibus (GEO)

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