Modulation of gene expression by complement protein C1q in amyloid-beta injured neurons

GSE28886

Rattus norvegicus

6 Downloadable Samples

Affymetrix Rat Gene 1.0 ST Array (ragene10st)

Submitter Supplied Information

Description

Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection.

PubMed ID

23150673

Publication Title

C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

Total Samples

Submitter’s Institution

UC Irvine

Authors

Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ

Source Repository

Gene Expression Omnibus (GEO)

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