In vitro knockdown of LAMP3 leads to down-regulation of interferon-inducible genes

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GSE29009

Homo sapiens

8 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

We identified LAMP3 as a key driver gene of anti-viral subnetwork genes in cervical cancer patients. Therefore we tested this prediction using an in vitro system. This is the first direct demonstration of LAMP3 regulatory role in interferon-dependent immune response.

PubMed ID

23651994

Publication Title

Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer.

Total Samples

Submitter’s Institution

NIAID, USA

Authors

Mine KL, Shulzhenko N, Yambartsev A, Rochman M, Sanson GF, Lando M, Varma S, Skinner J, Volfovsky N, Deng T, Brenna SM, Carvalho CR, Ribalta JC, Bustin M, Matzinger P, Silva ID, Lyng H, Gerbase-DeLima M, Morgun A

Source Repository

Gene Expression Omnibus (GEO)

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