Gene expression analysis of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.

GSE29956

Mus musculus

8 Downloadable Samples

Illumina mouseRef-8 v1.1 expression beadchip

Submitter Supplied Information

Description

Analysis of gene expression of prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated.The hypothesis tested in the present study was that mast cells inhibition or absence impacted prostate tumor development and histotype. Results demonstrate that prostate tumors arisen in TRAMP mice in which mast cells are pharmacologically stabilized or genetically ablated have a neuroendocrine signature.

PubMed ID

21896641

Publication Title

Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers.

Total Samples

Submitter’s Institution

IRCCS Istituto Nazionale dei Tumori

Authors

Pittoni P, Tripodo C, Piconese S, Mauri G, Parenza M, Rigoni A, Sangaletti S, Colombo MP

Source Repository

Gene Expression Omnibus (GEO)

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