Expression data from GW8510 treatment of pancreatic cells

GSE31102

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

Expression of insulin in terminally differentiated non-beta pancreatic cell types could be important for treating type-1 diabetes. We observed that the kinase inhibitor GW8510 up-regulated insulin expression in mouse pancreatic alpha cells.

PubMed ID

22242153

Publication Title

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

Total Samples

Submitter’s Institution

Broad Institute

Authors

Fomina-Yadlin D, Kubicek S, Vetere A, He KH, Schreiber SL, Wagner BK

Source Repository

Gene Expression Omnibus (GEO)

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