Transcript level in F9 teratocarcinoma WT and RARalpha knockout in presence and absence of all-trans retinoic acid

GSE31280

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Retinoic acid receptors (RARs) , and are key regulators of embryonic development. Hematopoietic differentiation is regulated by RAR, and several types of leukemia show aberrant RAR activity. We demonstrate that RAR plays an important role in cellular memory and imprinting by regulating the CpG methylation status of specific promoter regions.

PubMed ID

21911359

Publication Title

Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.

Total Samples

Submitter’s Institution

Weill Cornell Medical College

Authors

Laursen KB, Wong PM, Gudas LJ

Source Repository

Gene Expression Omnibus (GEO)

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