Effect of endoplasmic reticulum stress on gene expression in lymphoblastoid cell lines.

The ER stress inducing agent Thapsigargin (TG) and/or the cytoprotective agent Salubrinal were applied to lymphoblastoid cell lines. TG induced lytic replication as well as a distinct pattern of gene expression changes. This study was designed to identify host genes mediating lytic replication secondary to ER stress.

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Taylor GM, Raghuwanshi SK, Rowe DT, Wadowsky RM, Rosendorff A