Genome-wide analysis of lupus immune complex stimulation of purified CD14+ monocytes and how this response is regulated by C1q

GSE32278

Homo sapiens

8 Downloadable Samples

Illumina HumanRef-8 v3.0 expression beadchip

Submitter Supplied Information

Description

The goal of this study was to determine what genes are up- and down-regulated in response to lupus immune complexes in purified CD14+ monocyte stimulations. Our results have shown that novel genes are induced by immune complexes but the response is less robust when using purified monocytes versus total PBMCs

PubMed ID

22147767

Publication Title

Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes.

Total Samples

Submitter’s Institution

University of Washington

Authors

Santer DM, Wiedeman AE, Teal TH, Ghosh P, Elkon KB

Source Repository

Gene Expression Omnibus (GEO)

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