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Accession IconGSE33626

Tissue selective effects of topoisomerase II inhibitors in vivo

Organism Icon Mus musculus
Sample Icon 30 Downloadable Samples
Technology Badge IconIllumina HumanWG-6 v3.0 expression beadchip

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Description
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. In vitro experiments showed that doxorubicin can induce histone eviction as well as DNA damage, while etoposide can only induce DNA damage. Here, we compare the transcription responses of different tissues to doxorubicin or etoposide treatment in vivo.
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