Gene expression analysis in skeletal muscle and heart of 11 days-old TK2 knockout mice

GSE38449

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.1 ST Array (mogene11st)

Submitter Supplied Information

Description

TK2 deficiency causes severe mtDNA depeltion in several tissues, including skeletal muscle and heart. TK2 knockout mice grow slower and their skeletal muscles appeared significantly underdeveloped, whereas heart was close to normal size.

PubMed ID

23341978

Publication Title

Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells.

Total Samples

Submitter’s Institution

Karolinska Institute

Authors

Paredes JA, Zhou X, Höglund S, Karlsson A

Source Repository

Gene Expression Omnibus (GEO)

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