Expression data from AML1-ETO (AE)-expressing murine bone marrow (BM) cells treated with retinoids

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GSE39883

Mus musculus

18 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

AE-expressing murine BM cells treated with all-trans retinoic acid (ATRA) in semi-solid methycellulose-based cultures show an increase in self-renewal capacity whilst treatment with a specific RARa agonist NRX195183 reduces their clonogenicity. Gene expression analysis was performed to further investigate the molecular mechanisms underlying these observations. Upregulated gene sets were identified in the ATRA-treated AE BM cells.

PubMed ID

23228968

Publication Title

ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells.

Total Samples

Submitter’s Institution

Peter MacCallum Cancer Centre

Authors

Chee LC, Hendy J, Purton LE, McArthur GA

Source Repository

Gene Expression Omnibus (GEO)

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