Transcript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae

Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating between RNA changes induced by cisplatin which are dependent or independent of the Sky1 function.

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Rodríguez-Lombardero S, Vizoso-Vázquez Á, Lombardía LJ, Becerra M, González-Siso MI, Cerdán ME