Expression data from monocyte-derived macrophages after stimulation with mock, LPS, PolyI:C and P3C.

Pre-stimulation of MDMs with LPS (signals via MyD88 and TRIF dependent pathways) and PolyI:C (signals via a TRIF dependent pathway) leads to a reduced viral infection. In contrast, pre-stimulation with P3C (signals via MyD88 dependent pathway) does not lead to a reduced viral infection. This microarray was performed to find genes that are specifically upregulated in LPS and PolyI:C stimulated MDMs but not P3C stimulated MDMs. So to give us leads into the mechanism involved in the reduction of viral infection.

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Short KR, Vissers M, de Kleijn S, Zomer AL, Kedzierska K, Grant E, Reading PC, Hermans PW, Ferwerda G, Diavatopoulos DA