Gene expression profile in the heart of wild type and Adenosine Receptor A2a over expressing mice

Adenosine binds to 4 G protein-coupled receptors located on the cardiomyocyte (A1-R, A2a-R, A2b-R and A3-R) and modulates cardiac function during both ischemia and load-induced stress. While the role of adenosine receptor-subtypes has been well defined in the setting of ischemia-reperfusion, far less is known regarding their roles in protecting the heart during other forms of cardiac stress.

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Zhang L, Hamad EA, Vausort M, Funakoshi H, Feldman AM, Wagner DR, Devaux Y