Gene expression changes in Apc-mutant mouse intestinal organoids with and without deleting the Prox1 transcription factor

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GSE47568

Mus musculus

14 Downloadable Samples

Illumina MouseWG-6 v2.0 expression beadchip

Submitter Supplied Information

Description

We isolated and selected intestinal adenoma organoids from villin-CreER; Apcflox/flox and villin-CreER; Apcflox/flox; Prox1flox/flox mice and added tamoxifen to induce the deletion of the Apc and Prox1 genes in the intestinal epitheliul ex vivo. Microarray experiments were carried out 7 days after the addition of tamoxifen.

PubMed ID

25242330

Publication Title

Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance.

Total Samples

Submitter’s Institution

University of Helsinki

Authors

Wiener Z, Högström J, Hyvönen V, Band AM, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K

Source Repository

Gene Expression Omnibus (GEO)

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