Host directed activity of Pyrazinamide in Mycobacterium tuberculosis infection

Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). we have used human monocyte and a mouse model of pulmonary TB to investigate whether treatment with PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during Mycobacterium tuberculosis (Mtb) infection.

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Manca C, Koo MS, Peixoto B, Fallows D, Kaplan G, Subbian S