Effects of PP2Ac over-expression on mouse nave CD4 T cell gene profile upon activation

GSE49466

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

A transgenic mouse was generated using a CD2-driven transgene containing the cDNA of Ppp2ca to achieve over-expression of PP2Ac in T cells. Nave CD4 T cells were isolated and lysed at times 0, 6, and 24 hours after stimulation with anti-CD3 and anti-CD28

PubMed ID

23918926

Publication Title

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

Total Samples

Submitter’s Institution

Beth Israel Deaconess Medical Center

Authors

Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC

Source Repository

Gene Expression Omnibus (GEO)

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