Effects of Treg depletion in dystrophic muscle.

GSE50095

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

CD4+Foxp3+ regulatory T cells (Tregs) accumulate in skeletal muscle from dystrophin-deficient mdx mice. Analysis of global gene expression in muscles from mdx mice treated with anti-CD25 compared with muscles from mdx mice treated with control antibody revealed that Tregs partially protect mdx mice from muscle pathology and promote muscle repair/regeneration.

PubMed ID

24315098

Publication Title

A special population of regulatory T cells potentiates muscle repair.

Total Samples

Submitter’s Institution

Harvard Medical School

Authors

Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D

Source Repository

Gene Expression Omnibus (GEO)

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