AR function is altered by polyglutamine expansion and by SUMO

GSE50383

Rattus norvegicus

18 Downloadable Samples

Affymetrix Mouse Gene 2.1 ST Array (mogene21st)

Submitter Supplied Information

Description

Expansion of a polyglutamine (polyQ) tract in the gene for the androgen receptor (AR) results in partial loss of transactivation function and causes spinobulbar muscular atrophy (SBMA). Modification of AR by small ubiquitin-like modifier (SUMO) reduces AR function in a promoter context-dependent manner.

PubMed ID

25607844

Publication Title

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

Total Samples

Submitter’s Institution

University of Michigan

Authors

Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iñiguez-Lluhí JA, Lieberman AP

Source Repository

Gene Expression Omnibus (GEO)

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