DENV1-NS3hell single point mutations enhance viral replication and bypass Type I IFN anti-virus function in human dendritic cells

GSE50698

Homo sapiens

12 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

Dengue is one of the most important arboviruses in the world, with 2.5 billion people living in areas under risk to contagious. Mosquitos from Aedes genus is the transmission vector of viral particles.

PubMed ID

26340409

Publication Title

Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I interferon response.

Total Samples

Submitter’s Institution

Instituto Carlos Chagas

Authors

Silveira GF, Strottmann DM, de Borba L, Mansur DS, Zanchin NI, Bordignon J, dos Santos CN

Source Repository

Gene Expression Omnibus (GEO)

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