Expression profiles of E11.5 wildtype and Shox2 knockout embryonic forelimbs

The development of vertebrate extremities is a complex process which requires a highly coordinated network of different transcriptional activities. The homeodomain transcription factor Shox2 is a key player in limb formation controlling neural, muscular and skeletal development.

4

Glaser A, Arora R, Hoffmann S, Li L, Gretz N, Papaioannou VE, Rappold GA