Comparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes

Gene expression is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains. The testis-specific bromodomain protein tBRD-1 is essential for male fertility and might act as a co-factor of testis-specifc TAFs. Here, we perform microarray analyses and demonstrate that tBRD-1 selectively controls gene expression in male germ cells

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Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner SM, Leser K, Awe S, Schipper M, Renkawitz-Pohl R, Rathke C