p38 MAPK activation upregulates pro-inflammatory pathways in skeletal muscle cells from insulin resistant type 2 diabetic patients

GSE55650

Homo sapiens

21 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Skeletal muscle is the key site of peripheral insulin resistance in type 2 diabetes. Insulin-stimulated glucose uptake is decreased in differentiated diabetic myotubes in keeping with a retained genetic/epigenetic defect of insulin action.

PubMed ID

25370850

Publication Title

p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.

Total Samples

Submitter’s Institution

Newcastle University

Authors

Brown AE, Palsgaard J, Borup R, Avery P, Gunn DA, De Meyts P, Yeaman SJ, Walker M

Source Repository

Gene Expression Omnibus (GEO)

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