The Arabidopsis Mediator CDK8 module genes CCT and GCT are global regulators of developmental phase transitions.

Temporal coordination of developmental programs is necessary for normal ontogeny, but the mechanism by which this is accomplished is poorly understood. We have previously shown that two components of the Mediator CDK8 module, CENTER CITY (CCT/MED12) and GRAND CENTRAL (GCT/MED13), are required for timing of pattern formation during embryogenesis in Arabidopsis.

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Gillmor CS, Silva-Ortega CO, Willmann MR, Buendía-Monreal M, Poethig RS